Signals, regulatory networks, and materials that build and break bacterial biofilms.

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Comparison of MLP NN Approach with PCA and ICA for Extraction of Hidden Regulatory Signals in Biological Networks

The biologists now face with the masses of high dimensional datasets generated from various high-throughput technologies, which are outputs of complex inter-connected biological networks at different levels driven by a number of hidden regulatory signals. So far, many computational and statistical methods such as PCA and ICA have been employed for computing low-dimensional or hidden represe...

Effects of biofilm formation in bacteria from different perspectives

Bacterial communities are able to form complex and three-dimensional biofilm structures. Biofilm formation is an ancient and integral component of the prokaryotic life cycle and a key factor for survival in diverse niches. In biofilms, bacterial lifestyle changes from free-floating cells to sessile cells. Presence in biofilms gives new traits to bacteria, which distinguish them from free cells....

One-step purification and characterization of alginate lyase from a clinical Pseudomonas aeruginosa with destructive activity on bacterial biofilm

Objective(s): Pseudomonas aeruginosais a Gram-negative and aerobic rod bacterium that displays mucoid and non-mucoid phenotype. Mucoid strains secrete alginate, which is the main agent of biofilms in chronic P. aeruginosa infections, show high resistance to antibiotics; consequently, the biological disruption of mucoid P. aeruginosa biofilms is an attractive area of study for researchers. Algin...

The effect of bromhexine, gentamicin and imipenem on biofilm of standard bacterial Escherichia coli and Pseudomonas aeruginosa by ELISA method

Background: Biofilms are a collection of microorganisms that have the ability to stick to different levels. Due to the difficulty of treatment of bacterial biofilm infections and their lack of recognition by conventional diagnostic methods, this study aimed to provide a new method of identification and the effect of related drugs on Pseudomonas aeruginosa and Escherichia coli biofilms. Material...